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CH451- Biochemistry II Resources
WOU Chemistry Program Outcomes
Class Objectives and Goals
Week 1: Amino Acid Review and Carbohydrate Structure and Function
Week 2: Glycogen Biosynthesis and Metabolism
Week 3: Biochemical Energy Generation and Utilization
Week 4: Glycolysis
Week 5: Gluconeogenesis and the Kreb Cycle
Week 6: The Kreb Cycle, Electron Transport Chain, and Oxidative Phosphorylation
Week 7: Ethanol Metabolism and Reactive Oxygen Species
Week 8: Introduction to Lipids
Week 9: Lipid Metabolism
Week 10: Lipid Metabolism
WOU Chemistry Program Outcomes:
- Demonstrate an understanding of major concepts, theoretical principles and experimental findings in chemistry. (PS)
- Employ critical thinking and quantitative analytical skills to solve problems, and evaluate scientific data. (Q)
- Use and apply of laboratory methods and scientific instrumentation to investigate a scientific hypothesis, conduct experiments, analyze data, and interpret results. (IA)
- Demonstrate effective written and oral communication skills including the ability to transmit complex scientific or technical information in a clear and concise manner. (W)
- Gather, comprehend, apply, and communicate credible information on scientific and technical topics and recognize the proper use of scientific data, principles and theories to assess the quality of stated conclusions. (IA)
- Demonstrate ethical awareness and conduct with regards to: (1) honesty in data reporting; (2) the safety of practitioners, test subjects and the local community/environment; and (3) their social responsibility to recognize the impact that our actions have on the natural and human world. (PS)
Class Objectives and Goals:
This course is designed for upper division undergraduate students that are interested in learning about how life works. It is highly recommended for students that are interested in pursuing a graduate or professional degree in the medical sciences. The course is designed in two installments: Biochemistry I offered in the fall term, and Biochemistry II offered in the winter term. The focus of Biochemistry II is on carbohydrate and lipid metabolism, as well as the processes of cellular energy production and utilization. Within these process, we will engage in the detailed exploration of biological macromolecule structure and function with emphasis on the mechanisms of protein/ligand binding, metabolic pathways and regulatory enzyme mechanisms. By the end of the second quarter, you should be able to:
- Read background information, collect, analyze or interpret data for the purpose of oral discussion or written scientific reports or reviews.
Aligns to:- Chemistry Program Outcome 2
- ULO: Quantitative Literacy
- Prepare and present a project on a complex biochemical topic (could be in in the format of a video, blog, podcast, review paper, etc)
Aligns to:- Chemistry Program Outcomes 4 and 5
- ULO: Written Communication
- Explain how the metabolism of glucose leads ultimately to the generation of large quantities of ATP.
Aligns to:- Chemistry Program Outcome 1
- Describe how fats, proteins, and amino acids are metabolized, and explain how they can be used for fuel.
Aligns to:- Chemistry Program Outcome 1
- Explain the process of photosynthesis and the conversion of carbon dioxide into biomass
Aligns to:- Chemistry Program Outcome 1
Background Reading Sources:
Week 1: Amino Acid Review and Carbohydrate Structure and Function
- Review of Amino Acids and Chirality – Powerpoint Slides, PDF with Notes, Video Lecture
- Carbohydrates Part 1: Monosaccharide Structure – Powerpoint Slides, PDF with Notes, Video Lecture
- Carbohydrates Part 2: Monosaccharide Cyclization – Powerpoint Slides, PDF with Notes, Video Lecture
- Carbohydrates Part 3: Sugar Isomerase Enzymes – Powerpoint Slides, PDF with Notes, Video Lecture
- Carbohydrates Part 4: Disaccharides, Oligosaccharides, and Polysaccharides – Powerpoint Slides PDF with Notes, Video Lecture
- Carbohydrates Part 5: Sugar Derivatives and Their Functions – Powerpoint Slides, PDF with Notes, Video Lecture
Week 2: Glycogen Biosynthesis and Metabolism
- Insulin Signaling – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycogenesis – Powerpoint Slides, PDF with Notes, Video Lecture
- Glucagon Signaling in the Liver – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycogenolysis – Powerpoint Slides, PDF with Notes, Video Lecture
- Regulation of Glycogenolysis – Powerpoint Slides, PDF with Notes, Video Lecture
Week 3: Biochemical Energy Generation and Utilization
- The Neuron and Action Potential – Powerpoint Slides, PDF with Notes, Video Lecture
- Motor Proteins and Muscle Contraction – Powerpoint Slides, PDF with Notes, Video Lecture
- Glucose Uptake and ATP Recycling – Powerpoint Slides, PDF with Notes, Video Lecture
Week 4: Glycolysis
- Glycolysis Part 1: General Overview – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycolysis Part 2: Hexokinase Isozymes – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycolysis Part 3: Regulation of Phosphofructokinase-1 – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycolysis Part 4: Glyceraldehyde 3-Phosphate Dehydrogenase – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycolysis Part 5: The Last Four Reactions and the End of Glycolysis – Powerpoint Slides, PDF with Notes, Video Lecture
Week 5: Gluconeogenesis and the Kreb Cycle
- Gluconeogenesis Part 1: Pyruvate Carboxylase Enzyme – Powerpoint Slides, PDF with Notes, Video Lecture
- Gluconeogenesis Part 2: Malate-Aspartate Shuttle System – Powerpoint Slides, PDF with Notes, Video Lecture
- Gluconeogenesis Part 3: PEPCK and Glucose Production – Powerpoint Slides, PDF with Notes, Video Lecture
- Kreb Cycle Part 1: Introduction to the Pyruvate Dehydrogenase Complex – Powerpoint Slides, PDF with Notes, Video Lecture
Week 6: The Kreb Cycle, Electron Transport Chain, and Oxidative Phosphorylation
- Kreb Cycle Part 2: The Reactions – Powerpoint Slides, PDF with Notes, Video Lecture
- Electron Transport Chain Part 1: Complex I – The NADH/Q Oxidoreductase – Powerpoint Slides, PDF with Notes, Video Lecture
- Electron Transport Chain Part 2: Complex II – Succinate/Q Reductase – Powerpoint Slides, PDF with Notes, Video Lecture
- Electron Transport Chain Part 3: Complex III – The Q/Cytochrome C Oxidoreductase – Powerpoint Slides, PDF with Notes, Video Lecture
- Electron Transport Chain Part 4: Complex IV – Cytochrome C Oxidase – Powerpoint Slides, PDF with Notes, Video Lecture
- ATP Synthase Enzyme – Powerpoint Slides, PDF with Notes, Video Lecture
- Glycolysis – The Fate of NADH – Powerpoint Slides, PDF with Notes, Video Lecture
Week 7: Ethanol Metabolism and Reactive Oxygen Species
- Ethanol Production and Metabolism – Powerpoint Slides, PDF with Notes, Video Lecture
- Reactive Oxygen Species –Powerpoint Slides, PDF with Notes, Video Lecture
- Autophagy – Powerpoint Slides, PDF with Notes, Video Lecture
- Apoptosis – Powerpoint Slides, PDF with Notes, Video Lecture
Week 8: Introduction to Lipids
- Lipids Part 1: Fatty Acid Structure – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 2: Triacylglycerides – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 3: Phospoholipids – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 4: Waxes – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 5: Steroids – Powerpoint Slides, PDF with Notes, Video Lecture
Week 9: Lipid Metabolism
- Lipid Part 6: Digestion and Transportation – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 7: Adipose Tissue – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 8: Beta-Oxidation – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 9: The Energy of Lipids – Powerpoint Slides, PDF with Notes, Video Lecture
Week 10: Lipid Metabolism
- Lipids Part 10: Beta-Oxidation of Unsaturated Fatty Acids – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 11: Beta-Oxidation of Odd Chain and Unusual Fatty Acids – Powerpoint Slides, PDF with Notes, Video Lecture
- Lipids Part 12: Ketone Bodies – Powerpoint Slides, PDF with Notes, Video Lecture
