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Ch450 Biochemistry I – Student and Teacher Resources:
WOU Chemistry Program Outcomes:
- Demonstrate an understanding of major concepts, theoretical principles and experimental findings in chemistry. (PS)
- Employ critical thinking and quantitative analytical skills to solve problems, and evaluate scientific data. (Q)
- Use and apply of laboratory methods and scientific instrumentation to investigate a scientific hypothesis, conduct experiments, analyze data, and interpret results. (IA)
- Demonstrate effective written and oral communication skills including the ability to transmit complex scientific or technical information in a clear and concise manner. (W)
- Gather, comprehend, apply, and communicate credible information on scientific and technical topics and recognize the proper use of scientific data, principles and theories to assess the quality of stated conclusions. (IA)
- Demonstrate ethical awareness and conduct with regards to: (1) honesty in data reporting; (2) the safety of practitioners, test subjects and the local community/environment; and (3) their social responsibility to recognize the impact that our actions have on the natural and human world. (PS)
Class Objectives and Goals:
This course is designed for upper division undergraduate students that are interested in learning about how life works. It is highly recommended for students that are interested in pursuing a graduate or professional degree in the medical sciences. The course is designed in two installments: Biochemistry I offered in the fall term, and Biochemistry II offered in the winter term. The focus of Biochemistry II is on carbohydrate and lipid metabolism, as well as the processes of cellular energy production and utilization. Within these process, we will engage in the detailed exploration of biological macromolecule structure and function with emphasis on the mechanisms of protein/ligand binding, metabolic pathways and regulatory enzyme mechanisms. By the end of the second quarter, you should be able to:
- Read background information, collect, analyze or interpret data for the purpose of oral discussion or written scientific reports or reviews.
Aligns to:- Chemistry Program Outcome 2
- ULO: Quantitative Literacy
- Prepare and present a project on a complex biochemical topic (could be in in the format of a video, blog, podcast, review paper, etc)
Aligns to:- Chemistry Program Outcomes 4 and 5
- ULO: Written Communication
- Explain how the metabolism of glucose leads ultimately to the generation of large quantities of ATP.
Aligns to:- Chemistry Program Outcome 1
- Describe how fats, proteins, and amino acids are metabolized, and explain how they can be used for fuel.
Aligns to:- Chemistry Program Outcome 1
- Explain the process of photosynthesis and the conversion of carbon dioxide into biomass
Aligns to:- Chemistry Program Outcome 1
Background Reading Sources:
Chapter 1: The Foundations of Biochemistry
Lecture 1.1 – Cellular Foundations; Lecture 1.1: Cellular Foundations PDF with Notes; Youtube Lecture 1.1
Lecture 1.2 – Physical Foundations; Lecture 1.2 PDF with Notes; Youtube Lecture 1.2
Lecture 1.3 Chemical Foundations; Lecture 1.3 PDF with Notes; Youtube Lecture 1.3
Lecture 1.4 genetics and evolution; Chapter 1.4 PDF with Notes; Youtube Lecture 1.4
Chapter 2: Protein Structure
Chapter 2 Powerpoint Slides; Chapter 2 PDF with Notes
Youtube Lecture 2.1 Amino Acid Structure and Properties
Youtube Lecture 2.2 Peptide Bond Formation and Primary Structure
Youtube Lecture 2.3 Secondary Protein Structure
Youtube Lecture 2.4 Supersecondary Protein Structure
Youtube Lecture 2.5 Tertiary and Quaternary Protein Structure
Youtube Lecture 2.6 Protein Folding, Denaturation and Hydrolysis
Chapter 3: Investigating Proteins
Chapter 3 Powerpoint Slides; Chapter 3 Slides PDF with Notes
Youtube Lecture 3.1 Protein Purification
Youtube Lecture 3.2 part 1: Protein Identification and Visualization
Youtube Lecture 3.2 part 2: Protein Identification and Visualization
Youtube Lecture 3.3 Protein Synthesis and Sequencing
Youtube Lecture 3.4 Protein Structure Elucidation
Chapter 4: DNA, RNA and the Human Genome
Chapter 4 Powerpoint Slides; Chapter 4 Slides PDF with Notes
Youtube Lecture 4.1 DNA and RNA Structure
Youtube Lecture 4.2 Chromosomes and Packaging
Youtube Lecture 4.3 Sequencing the Human Genome
Chapter 5: Investigating DNA
Chapter 5.1 Powerpoint Slides; Chapter 5.1 PDF with Notes
Chapter 5 Powerpoint Slides Sections 5.2 – 5.5;Lecture 5.2 to 5.5 PDF with Notes
Youtube Lecture 5.1.1 DNA and RNA Isolation and Purification
Youtube Lecture 5.1.2 DNA Sequencing Techniques
Youtube Lecture 5.1.3 DNA Synthesis Techniques
Youtube Lecture 5.2 and 5.3 Bioinformatics and DNA Cloning
Youtube Lecture 5.3 to 5.5 CRISPR/Cas Technologies, DNA Microarrays, and In Situ Hybridization
Chapter 6: Enzyme Principles and Biotechnological Applications
Chapter 6.1 to 6.4 Powerpoint Slides; Lecture 6.1 to 6.4 PDF with Notes
Chapter 6.5 to 6.10 Powerpoint Slides; Lecture 6.5 – 6.8 PDF with Notes
Youtube Lecture 6.1 to 6.2 Enzyme Nomenclature and Classification
Youtube Lecture 6.3 to 6.4 Enzyme Substrate Binding and Reaction Equilibrium
Youtube Lecture 6.5 Properties and Mechanisms of Enzyme Action
Youtube Lecture 6.6 and 6.7 pH, Temperature, and Mechanisms of Enzyme Inhibition
Youtube Lecture 6.8 Allosteric Enzymes
Chapter 7: Catalytic Mechanisms of Enzymes
Chapter 7.1 to 7.3 Chymotrypsin Powerpoint Slides; Lecture 7.1 to 7.3 Chymotrypsin PDF with Notes
Chapter 7.3 Part 2 Powerpoint Slides; Chapter 7.3 Part 2 PDF with Notes
Youtube Lecture 7.1 Review of Organic Chemistry Concepts
Youtube Lecture 7.2 and 7.3 Catalytic Mechanisms of Enzymes: Chymotrypsin
Youtube Lecture 7.3 Proteases and NMP Kinases
Youtube Lecture 7.3 Restriction Endonucleases
Youtube Lecture 7.3 RNA Enzymes (Ribozymes)
Chapter 8: Protein Regulation and Degradation
Chapter 8.1 to 8.4 Powerpoint Slides; Chapter 8.1 to 8.4 PDF with Notes
Chapter 8.5 Powerpoint Slides; Chapter 8.5 PDF with Notes
Youtube Lecture 8.2 Post-Translational Modifications
Youtube Lectures 8.3 and 8.4 Allosteric Enzymes and Zymogens
Youtube Lecture 8.5 Intracellular Protein Degradation
Chapter 9: DNA Replication
Chapter 9.1 and 9.2 Powerpoint Slides; Chapter 9.1 and 9.2 PDF with Notes
Chapter 9.3 to the end Powerpoint Slides; Chapter 9.3 to the end PDF with Notes
Youtube Lecture Chapter 9.1 DNA Replication is Semiconservative
Youtube Lecture Chapter 9.2 Part 1: Prokaryotic DNA Replication
Youtube Lecture Chapter 9.2 Part 2: Prokaryotic DNA Replication
Youtube Lecture Chapter 9.3 Replication of Extrachromosomal Elements
Youtube Lecture Chapter 9.4 Eukaryotic DNA Replication Part 1 – The Cell Cycle
Youtube Lecture Chapter 9.4 Eukartyotic DNA Replication Part 2 – The Major Players
Youtube Lecture Chapter 9.5 Mitochondrial DNA Replication
Youtube Lecture Chapter 9.6 Replication of Telomeres
Chapter 10: Transcription and RNA Processing
Chapter 10 Powerpoint Slides; Chapter 10 PDF with Notes
Youtube Lecture Chapter 10.1 Types of RNA
Youtube Lecture Chapter 10.2 RNA Polymerase Enzymes
Youtube Lecture Chapter 10.3 Transcription Factors and the Preinitiation Complex
Youtube Lecture Chapter 10.4 Transcription Elongation and Termination
Youtube Lecture Chapter 10.5 Processing of RNA
Chapter 11: Translation
Chapter 11.1 to 11.3 Powerpoint Slides; Chapter 11.1 to 11.3 PDF with Notes
Youtube Lecture Chapter 11.1 Overview of Translation
Youtube Lecture Chapter 11.2 Transfer RNA (tRNA)
Youtube Lecture Chapter 11.3 Aminoacyl-tRNA Synthetases
More to come soon!
Chapter 12: DNA Damage and Repair
More to come soon!
Chapter 13: Transcriptional Control and Epigenetics
more to come soon!
